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拉曼光谱技术的应用


拉曼光谱由于可以无损的得到关于分子种类、浓度、应力、相与形态等信息,因而在多个领域中都有应用。拉曼光谱技术主要可以应用在以下几个领域:生命科学,材料科学,分析科学,药学,化学科学与地球科学。


图 1 拉曼光谱技术的应用领域


#生命科学



可以将拉曼光谱学用于[1]


癌症研究/病理学 Ÿ

蛋白质/缩氨酸结构分析 Ÿ

体外和体内给药的药物动力学 Ÿ

老龄化和神经退行性疾病 Ÿ

生物燃料和农业研究 Ÿ

脂类组学 代谢组学 Ÿ

发育生物学 生殖生物学 Ÿ

病毒学


#材料科学



可以将拉曼光谱学用于


碳材料的研究、开发和质量控制[2];

分析碳纳米形态的尺寸,缺陷; Ÿ 描绘半导体特性,得到半导体的化学构成,应力,浓度,晶体结构[3]; Ÿ

了解光伏材料特性,包括电子效率,应力,薄膜厚度,晶体质量[4]; Ÿ

分析催化系统,包括催化相的鉴别, 研究反应机制[5]; Ÿ

电池技术,识别电池各部分组件[6]。


#分析科学



可以将拉曼光谱学用于


艺术品文物,包括分析颜料和油漆。

确定文物真伪,确定纸张成分[7-9] Ÿ

检测毒品[10-14] Ÿ

食品农药残留[15-17] Ÿ

水果糖度[18,19] Ÿ

识别爆炸物和枪击残留物的痕迹[20-22] Ÿ

探测污染物,包括半导体,金属,大气中的污染物[23-25]


#药学



可以将拉曼光谱学用于


药品中化合物的分布[26, 27] Ÿ

粉末的组成与浓度[28,29] Ÿ

识别区分API多形体和赋型剂[30,31] Ÿ

识别污染物[32]


#化学科学



可以将拉曼光谱学用于


识别混合物中各聚合物种类[33,34] Ÿ

分析纤维的应力[35,36] Ÿ

研究新型聚合物,比如导电聚合物[37,38] Ÿ

识别描绘化学反应产物[39,40] Ÿ

研究微流体中微量物质[41]


#地球科学



可以将拉曼光谱学用于


识别矿物质和其多形体[42-45] Ÿ

薄切片中颗粒的分布[46,47] Ÿ

透明物质里的包裹体的成像

鉴别宝石真伪[48 50] Ÿ

确认宝石缝隙是否被填充过 Ÿ

研究晶体缺陷


【参考文献】



[1] Movasaghi Z, Rehman S, Rehman I U. Raman spectroscopy of biological tissues[J]. Applied Spectroscopy Reviews, 2007, 42(5): 493-541. [2] MLA Dresselhaus, Mildred S., et al. "Raman spectroscopy of carbon nanotubes." Physics reports 409.2 (2005): 47-99.

[3] Tu, An, and P. D. Persans. "Raman scattering as a compositional probe of II‐VI ternary semiconductor nanocrystals." Applied physics letters 58.14 (1991): 1506-1508.

[4] Green, Martin A. "Third generation photovoltaics: Ultra‐high conversion efficiency at low cost." Progress in Photovoltaics: Research and Applications 9.2 (2001): 123-135.

[5] Stencel, John M. "Raman spectroscopy for catalysis." (1989).

[6] Hardwick, Laurence J., et al. "Raman study of lithium coordination in EMI‐TFSI additive systems as lithium‐ion battery ionic liquid electrolytes." Journal of Raman Spectroscopy 38.1 (2007): 110-112.

[7] Colomban, Philippe. "The on‐site/remote Raman analysis with mobile instruments: a review of drawbacks and success in cultural heritage studies and other associated fields." Journal of Raman Spectroscopy 43.11 (2012): 1529-1535.

[8] Madariaga, Juan Manuel. "Raman spectroscopy in art and archaeology." Journal of Raman Spectroscopy 41.11 (2010): 1389-1393.

[9] Vandenabeele, Peter, et al. "Analysis with micro-Raman spectroscopy of natural organic binding media and varnishes used in art." Analytica Chimica Acta 407.1 (2000): 261-274.

[10] Ryder, Alan G., Gerard M. O'Connor, and Thomas J. Glynn. "Identifications and quantitative measurements of narcotics in solid mixtures using near-IR Raman spectroscopy and multivariate analysis." Journal of Forensic Science 44.5 (1999): 1013-1019.

[11] Thomas, J., Alan G. Ryder, and Gerard M. O'Connor. "Quantitative analysis of cocaine in solid mixtures using Raman spectroscopy and chemometric methods." Journal of Raman Spectroscopy (2000).

[12] Hargreaves, Michael D., et al. "Analysis of seized drugs using portable Raman spectroscopy in an airport environment—a proof of principle study." Journal of Raman Spectroscopy 39.7 (2008): 873-880.

[13] Yang, Yong, et al. "Controlled fabrication of silver nanoneedles array for SERS and their application in rapid detection of narcotics." Nanoscale 4.8 (2012): 2663-2669.

[14] Stokes, Robert J., et al. "New capability for hazardous materials ID within sealed containers using a portable spatially offset Raman spectroscopy (SORS) device." Society of Photo-Optical Instrumentation Engineers (SPIE) Conference Series. Vol. 9995. 2016.

[15] Dhakal, Sagar, et al. "Prototype instrument development for non-destructive detection of pesticide residue in apple surface using Raman technology." Journal of Food Engineering 123 (2014): 94-103.

[16] Liu, Bin, et al. "Detection of pesticides in fruits by surface-enhanced Raman spectroscopy coupled with gold nanostructures." Food and Bioprocess Technology 6.3 (2013): 710-718.

[17] Shende, Chetan, et al. "Inspection of pesticide residues on food by surface-enhanced Raman spectroscopy." Proceedings of SPIE. Vol. 5271. 2003.

[18] Nikbakht, A. M., et al. "Nondestructive determination of tomato fruit quality parameters using Raman spectroscopy." Journal of Agricultural Science and Technology 13 (2011): 517-526.

[19] Delfino, I., et al. "Visible micro-Raman spectroscopy for determining glucose content in beverage industry." Food chemistry 127.2 (2011): 735-742.

[20] Murthy, M. S. S. "Raman Effect: From Studying Cells to Detecting Bombs." (2016).

[21] Moore, David S., and R. Jason Scharff. "Portable Raman explosives detection." Analytical and bioanalytical chemistry 393.6-7 (2009): 1571-1578.

[22] Tuschel, David D., et al. "Deep ultraviolet resonance Raman excitation enables explosives detection." Applied spectroscopy 64.4 (2010): 425-432.

[23] BurmáKyong, Jin, and Eun KyuáLee. "Ultra-sensitive trace analysis of cyanide water pollutant in a PDMS microfluidic channel using surface-enhanced Raman spectroscopy." Analyst 130.7 (2005): 1009-1011.

[24] Cheng, Yan, and Yiyang Dong. "Screening melamine contaminant in eggs with portable surface-enhanced Raman spectroscopy based on gold nanosubstrate." Food Control 22.5 (2011): 685-689.

[25] Hennigan, Michelle C., and Alan G. Ryder. "Quantitative polymorph contaminant analysis in tablets using Raman and near infra-red spectroscopies." Journal of pharmaceutical and biomedical analysis 72 (2013): 163-171.

[26] Zhang, Lin, Mark J. Henson, and S. Sonja Sekulic. "Multivariate data analysis for Raman imaging of a model pharmaceutical tablet." Analytica Chimica Acta 545.2 (2005): 262-278.

[27] Shinzawa, Hideyuki, et al. "Raman imaging analysis of pharmaceutical tablets by two-dimensional (2D) correlation spectroscopy." Vibrational Spectroscopy 51.1 (2009): 125-131.

[28] Vankeirsbilck, Tineke, et al. "Applications of Raman spectroscopy in pharmaceutical analysis." TrAC trends in analytical chemistry 21.12 (2002): 869-877.

[29] De Beer, Thomas, et al. "Near infrared and Raman spectroscopy for the in-process monitoring of pharmaceutical production processes." International Journal of Pharmaceutics 417.1 (2011): 32-47.

[30] Larkin, Peter J., et al. "Polymorph characterization of active pharmaceutical ingredients (APIs) using low-frequency Raman spectroscopy." Applied spectroscopy 68.7 (2014): 758-776.

[31] Campeta, Anthony M., et al. "Development of a targeted polymorph screening approach for a complex polymorphic and highly solvating API." Journal of pharmaceutical sciences 99.9 (2010): 3874-3886.

[32] Hennigan, Michelle C., and Alan G. Ryder. "Quantitative polymorph contaminant analysis in tablets using Raman and near infra-red spectroscopies." Journal of pharmaceutical and biomedical analysis 72 (2013): 163-171.

[33] Rao, G. Ramana, et al. "Probing the structure of polymer blends by vibrational spectroscopy: the case of poly (ethylene oxide) and poly (methyl methacrylate) blends." Polymer 26.6 (1985): 811-820.

[34] Garton, Andrew, David N. Batchelder, and Chunwei Cheng. "Raman microscopy of polymer blends." Applied spectroscopy 47.7 (1993): 922-927.

[35] Sakata, H., et al. "Effect of uniaxial stress on the Raman spectra of graphite fibers." Journal of applied physics 63.8 (1988): 2769-2772. [36] Galiotis, C. "A study of mechanisms of stress transfer in continuous-and discontinuous-fibre model composites by laser Raman spectroscopy." Composites Science and Technology 48.1-4 (1993): 15-28.

[37] Lefrant, S., J. P. Buisson, and H. Eckhardt. "Raman spectra of conducting polymers with aromatic rings." Synthetic Metals 37.1-3 (1990): 91-98.

[38] Furukawa, Yukio, et al. "1064-nanometer-excited Fourier transform Raman spectroscopy of conducting polymers." Spectrochimica Acta Part A: Molecular Spectroscopy 47.9-10 (1991): 1367-1373.

[39] Howard Jr, Wilmont F., and Lester Andrews. "Infrared and Raman studies of alkali metal-chlorine reaction products. Resonance Raman spectrum of the chlorine molecular anion, Cl2." Inorganic Chemistry 14.4 (1975): 767-771.

[40] Aarnoutse, Petra J., and Johan A. Westerhuis. "Quantitative Raman reaction monitoring using the solvent as internal standard." Analytical chemistry 77.5 (2005): 1228-1236.

[41] Chen, Lingxin, and Jaebum Choo. "Recent advances in surface‐enhanced Raman scattering detection technology for microfluidic chips." Electrophoresis 29.9 (2008): 1815-1828.

[42] Bensted, John. "Uses of Raman spectroscopy in cement chemistry." Journal of the American Ceramic Society 59.3‐4 (1976): 140-143. [43] Karr, Clarence, ed. Infrared and Raman spectroscopy of lunar and terrestrial minerals. Elsevier, 2013.

[44] Frost, Ray L., et al. "Raman spectroscopy of three polymorphs of BiVO4: clinobisvanite, dreyerite and pucherite, with comparisons to (VO4) 3‐bearing minerals: namibite, pottsite and schumacherite." Journal of Raman Spectroscopy 37.7 (2006): 722-732.

[45] Čejka, Jiří, et al. "A vibrational spectroscopic study of hydrated Fe 3+ hydroxyl-sulfates; polymorphic minerals butlerite and parabutlerite." Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 79.5 (2011): 1356-1363.

[46] Velde, B., and H. Boyer. "Raman microprobe spectra of naturally shocked microcline feldspars." Journal of Geophysical Research: Solid Earth 90.B5 (1985): 3675-3681.

[47] Kudryavtsev, Anatoliy B., et al. "In situ laser-Raman imagery of Precambrian microscopic fossils." Proceedings of the National Academy of Sciences 98.3 (2001): 823-826.

[48] Bersani, Danilo, and Pier Paolo Lottici. "Applications of Raman spectroscopy to gemology." Analytical and bioanalytical chemistry 397.7 (2010): 2631-2646.

[49] Barone, Germana, et al. "A portable versus micro‐Raman equipment comparison for gemmological purposes: the case of sapphires and their imitations." Journal of Raman Spectroscopy 45.11-12 (2014): 1309-1317.

[50] Barone, G., et al. "APPLICATION OF MICRO-RAMAN SPECTROSCOPY FOR GEMSTONES CHARACTERIZATION. THE CASE OF RUBIES." AIAR VIII Congresso Nazionale di Archeometria Scienze e Beni Culturali: stato dell? arte e prospettive. 2014.


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